Neuroleptics And Alzheimer’s Disease
The term dementia is used to indicate a group of symptoms that occur due to the disruption of the mental faculties. The patients are unable to remember, take note of, coordinate and react to, the various cues and objects. It is one of the most common complaints of neurodegenerative disorders.
Dementia causes behavioral changes, especially mania among patients affected with Alzheimer’s disease. The Alzheimer’s disease dementia is treated effectively by using both typical and atypical antipsychotics. Neuroleptics (antipsychotics used to decrease mania) are widely used for treating dementia in elders.
Adverse Sensitivity Reactions that Occur due to Neuroleptic Use
However, these elders are found to witness severe, at times fatal repercussions due the use of neuroleptics. It starts with confusion and ends in severe symptoms such as senile dementia. Use of neuroleptics have been proved to be counter productive.
General Side Effects of Neuroleptics
Other types of side effects of neuroleptics are also witnessed in Alzheimer’s patients. These adverse symptoms are of both acute (severe) and chronic (long lasting) nature. The morbidity is found be more prevalent in elders.
Acute Adverse Effects of Neuroleptic Use
Acute adverse side effects are extrapyramidal symptoms (involuntary and unintentional stereotype movements), cardiovascular toxicity, anticholinergic effects (sleep disturbances, constipation, blurred vision and dizziness).
Chronic Adverse Effect: Tardive dyskinesia is one of the most important chronic adverse side effects.
Neuroleptics and Weight Loss
Various studies have reported that Alzheimer’s affected patients despite systematic treatment experience weight loss. The cause of this weight loss and malnourishment is still not established clearly. However, neuroleptics are found be be very effective in reversing and arresting the weight loss.